A 3D nanostructured calcium-aluminum-silicate scaffold with hierarchical meso-macroporosity for bone tissue regeneration: Fabrication, sintering behavior, surface modification and in vitro studies

نویسندگان

چکیده

This is a comprehensive study reporting the fabrication of highly porous Gehlenite scaffold (Ca2Al2SiO7)—both with and without surface modification—for first time. The sintering temperature scaffolds was optimized. Next, optimized coated by polycaprolactone (PCL)-Forsterite (Mg2SiO4) nanocomposite to improve scaffold’s brittleness biological properties. 1375 °C found be which consolidated. Different PCL Forsterite concentrations were separately applied on yield complete coating clogging macroporous structure. bioactivity, degradation rate, cell viability, attachment proliferation three different scaffolds—non-coated (sintered at °C), PCL-coated PCL/Forsterite nanocomposite-coated—were scrutinized compared each other in vitro. Based our results, it concluded that PCL-Forsterite nanocomposite-coated desired physical, chemical biological-related properties has great potential for bone tissue regeneration.

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ژورنال

عنوان ژورنال: Journal of The European Ceramic Society

سال: 2021

ISSN: ['0955-2219', '1873-619X']

DOI: https://doi.org/10.1016/j.jeurceramsoc.2020.07.073